副教授、教育部新世紀(jì)優(yōu)秀人才

北京醫(yī)科大學(xué)本科及碩士研究生畢業(yè)(1991-1999)，美國馬里蘭大學(xué)博士畢業(yè)(2004)。北京大學(xué)基礎(chǔ)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)系副教授。2009年入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”，2011年獲北京大學(xué)綠葉生物醫(yī)藥杰出青年學(xué)者獎(jiǎng)。以第一作者或責(zé)任作者身份發(fā)表研究性論文7篇，2013年受邀在《Annual Review of Physiology》發(fā)表題為“Estrogen and Cancer”的綜述一篇。

電話：82801397 郵箱：liang_jing@hsc.pku.edu.cn

主要研究方向、成就

重點(diǎn)研究組蛋白修飾酶及識(shí)別因子在腫瘤發(fā)生發(fā)展和轉(zhuǎn)移中的功能及分子機(jī)理。對(duì)轉(zhuǎn)錄抑制因子CDYL的系統(tǒng)性的功能學(xué)、進(jìn)化發(fā)生、分子作用機(jī)制及細(xì)胞生物學(xué)功能進(jìn)行了全方位探索。

承擔(dān)課題

1. 國家自然科學(xué)基金面上項(xiàng)目：轉(zhuǎn)錄抑制因子CDYL 調(diào)控組蛋白甲基化遺傳及巴豆?；傻难芯?#31371301，2014-2017)

2. 科技部973項(xiàng)目課題：腫瘤治療前后的異質(zhì)性與抗藥性演化機(jī)制(#2014CB542004，2014-2018)

3. 國家自然科學(xué)基金面上項(xiàng)目：CDYL介導(dǎo)H3K27甲基化酶EZH2的組蛋白識(shí)別及二者在乳腺癌發(fā)生中的機(jī)理研究(#30971637，2010-2012)

4. 教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃：基因轉(zhuǎn)錄調(diào)控與腫瘤發(fā)生(# NCET-10-0184，2010-2012)

代表性論文(第一#或責(zé)任作者*)

1. Cai Qi, Shumeng Liu, Rui Qin, Yu Zhang, Guoqiang Wang, Yongfeng Shang, Yun Wang* and Jing Liang* (2014) Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. Journal of Neuroscience 34:4494-508

2. Yu Zhang, Jing Liang* and Qian Li* (2014) Coordinated regulation of retinoic acid signaling pathway by KDM5B and polycomb repressive complex 2. Journal of Cellular Biochemistry 115:1528-38

3. Xiaohan Yang, Jianguo Yang, Lei Li, Luyang Sun, Xia Yi, Xiao Han, Wenzhe Si, Ruorong Yan, Zhe Chen, GuojiaXie, Wanjin Li, Yongfeng Shang, and Jing Liang* (2014) PAAT, a novel ATPase and trans-regulator ofmitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB Journal 28:4821-34

4. Jing Liang# and Yongfeng Shang* (2013) Estrogen and Cancer. Annual Review of Physiology 75:225-40

5. Yu Zhang, Xiaohan Yang, Bin Gui, GuojiaXie, Di Zhang, Yongfeng Shang, and Jing Liang* (2011) Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27. Journal of Biological Chemistry 286: 42414-25

6. Jing Liang#, Hua Zhang, Yu Zhang, Ying Zhang, and Yongfeng Shang* (2009) GAS, a novel glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO Reports 10:51-7

7. Xin Li#, Jing Liang#, Haijing Yu, Bing Su, Chunjie Xiao, Yongfeng Shang, Wen Wang. Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23:427-431

8. Bin Shi#, Jing Liang#, Xiaohan Yang, Yan Wang, Youna Zhao, Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Ruifang Li, Yu Zhang, Mei Hong, and Yongfeng Shang* (2007). Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells. Molecular and Cellular Biology 27:5105-19

9. Jing Liang#, Chaobo Yin, Howard Doong, Shengyun Fang, Corrine Peterhoff, Ralph A. Nixon and Mervyn J. Monteiro (2006) Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. Journal of Cell Science 119: 4011-24