副教授、病理檢驗(yàn)教研室副主任

教育及工作經(jīng)歷：

1996年畢業(yè)于哈爾濱醫(yī)科大學(xué)臨床醫(yī)學(xué)系，獲學(xué)士學(xué)位。同年留校工作，2000年獲哈爾濱醫(yī)科大學(xué)病理學(xué)專業(yè)碩士學(xué)位。2003年畢業(yè)于北京大學(xué)醫(yī)學(xué)部腫瘤學(xué)專業(yè)，獲博士學(xué)位。同年留北京大學(xué)腫瘤醫(yī)院病理科工作，歷任主治醫(yī)師、副主任醫(yī)師、副教授、主任醫(yī)師;2014年美國(guó)Mayo Clinic病理科訪問學(xué)者。

學(xué)術(shù)任職：

北京癌癥防治學(xué)會(huì)胃癌防治專業(yè)委員會(huì)副主任委員;

北京癌癥防治學(xué)會(huì)食管癌專業(yè)委員會(huì)委員;

北京腫瘤學(xué)會(huì)病理專業(yè)委員會(huì)委員;

北京醫(yī)學(xué)會(huì)病理學(xué)分會(huì)消化病理學(xué)組委員;

國(guó)家癌癥中心國(guó)家腫瘤質(zhì)控中心胃癌質(zhì)控專家委員會(huì)委員;

中國(guó)抗癌協(xié)會(huì)腫瘤病理專業(yè)委員會(huì)青年委員會(huì)委員;

中國(guó)抗癌協(xié)會(huì)腫瘤病理專業(yè)委員會(huì)胃腸中青年協(xié)作組(學(xué)組)委員;

中國(guó)抗癌協(xié)會(huì)腫瘤病理專委會(huì)大數(shù)據(jù)學(xué)組組員;

中國(guó)抗癌協(xié)會(huì)腫瘤病理專業(yè)委員會(huì)肝臟病理學(xué)組委員;

中國(guó)研究型醫(yī)院學(xué)會(huì)精準(zhǔn)醫(yī)學(xué)與腫瘤MDT專業(yè)委員會(huì)委員;

中華病理學(xué)雜志 通訊編委。

專長(zhǎng)：

從業(yè)20余年，經(jīng)過系統(tǒng)嚴(yán)格的專業(yè)培訓(xùn)，具有扎實(shí)全面的腫瘤病理診斷技能與豐富的腫瘤病理臨床經(jīng)驗(yàn)，擅長(zhǎng)胃、肝膽胰腺腫瘤的病理診斷及分子病理研究;主持北京市科技新星計(jì)劃課題、人社部留學(xué)人員科技活動(dòng)擇優(yōu)項(xiàng)目及首都衛(wèi)生發(fā)展科研專項(xiàng)，并參與科技部重點(diǎn)項(xiàng)目、國(guó)自然重點(diǎn)項(xiàng)目及國(guó)家973，863等項(xiàng)目研究。參譯專著《手術(shù)中病理診斷圖鑒》《軟組織腫瘤》、《腫瘤組織病理學(xué)診斷》、《癌前病變》，參編專著《胃癌》。獲國(guó)際發(fā)明專利1項(xiàng)、國(guó)家發(fā)明專利1項(xiàng);以第一作者及通訊作者發(fā)表SCI論文及國(guó)內(nèi)核心雜志論文20余篇;獲北京市衛(wèi)生系統(tǒng)高層次衛(wèi)生技術(shù)人才學(xué)科骨干。

發(fā)表論文(第一作者及通訊作者)

1. Su F, Li J, Zhao X, Wang B, Hu Y, Sun Y*, Ji J. Interpretable tumor differentiation grade and microsatellite instability recognition in gastric cancer using deep learning. Lab Invest. 2022 Feb 17. doi: 10.1038/s41374-022-00742-6. Epub ahead of print. PMID: 35177797.

2. Hu Y, Su F, Dong K, Wang X, Zhao X, Jiang Y, Li J, Ji J, Sun Y*. Deep learning system for lymph node quantification and metastatic cancer identification from whole-slide pathology images. Gastric Cancer. 2021;24(4):868-877.

3. Yu J, Cao F, Zhao X, Xie Q, Lu M, Li J, Yang Z*, Sun Y*. Correlation and comparison of somatostatin receptor type 2 immunohistochemical scoring systems with 68Ga-DOTATATE PET/CT imaging in gastroenteropancreatic neuroendocrine neoplasms. Neuroendocrinology. 2021 Jun 2. doi: 10.1159/000517530. Epub ahead of print.

4. #Su F, #Sun Y, #Hu Y, #Yuan P, Wang X, Wang Q, Li J, Ji JF*. Development and validation of a deep learning system for ascites cytopathology interpretation. Gastric Cancer. 2020;23(6):1041-1050.

5. Wang XY, Zheng ZX, Sun Y*, Bai YH, Shi YF, Zhou LX, Yao YF, Wu AW, Cao DF. Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas. World J Gastrointest Oncol. 2019;11(4):335-347.

6. Yu Sun,Christine Lohse,Thomas Smyrk,Timothy Hobday,Trynda Kroneman,Lizhi Zhang*. The Influence of Tumor Stage on the Prognostic Value of Ki-67 Index and Mitotic Count in Small Intestinal Neuroendocrine Tumors. Am J Surg Pathol 2018;42(2):247-255

7. Qinxiang Guo #,Yu Sun #,Sifan Yu,Hua Bai,Jun Zhao,Minglei Zhuo, Jie Wang. Programmed cell death-ligand 1 (PD-L1) expression and fibroblast growth factor receptor 1 (FGFR1) amplification in stage III/IV lung squamous cell carcinoma (SQC). Thoracic Cancer 2017;8:73–79

8. Yu Sun, Fei Yang, Xiao-Yan Zhou, Li-Xin Zhou, Xiang-Hong Li, Ning Lv, Jian-Ming Ying, Xiang Du. Concordance of immunohistochemistry and fluorescent in situ hybridization for anaplastic lymphoma kinase (ALK) rearrangement in non-small cell lung cancer: results from a multicenter study in China. Int J Clin Exp Med 2016;9(2):2642-2653

9. Zheng ZX #, Sun Y #, Bu ZD, Zhang LH, Li ZY, Wu AW, Wu XJ, Wang XH, Cheng XJ, Xing XF, Du H, Ji JF. Intestinal stem cell marker LGR5 expression during gastric carcinogenesis.World J Gastroenterol. 2013 ;19(46):8714-21

10. Yu Sun, Meng-meng Tian, Li-xin Zhou, Wei-cheng You, Ji-you Li. Value of C-Met for Predicting Progression of Precancerous Gastric Lesions in Rural Chinese Population. Chin J Cancer Res. 2012;24(1):18-22

11. Meng-Meng Tian#, Yu Sun#, Zhong-Wu Li, Ying Wu, Ai-Lian Zhao, Ji-You Li. Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis. World J Gastroenterol 2012; 18(4): 368-374

12. Yu Sun, Zhong-Wu Li, Guo-Shuang Feng, Ji-You Li. Long-term Follow-up Study on Gastric Intestinal Metaplasia Subtype and Its Relation to Expression of P53, Bcl-2 and PCNA. Chin J Cancer Res. 2009;21(4):272-277

13. Y Sun, J-Y Li, J-S He, L-X Zh, K Chen. Tissue Microarray Analysis of Multiple Gene Expression in Intestinal Metaplasia, Dysplasia and Carcinoma of Stomach. Histopathology. 2005;46(5):505-14

14. Yu Sun, Dajun Deng, Wei-Cheng You, Hua Bai, Lian Zhang, Jing Zhou, Lin Shen, Jun-Ling Ma, Yu-Quan Xie, and Ji-You Li. Methylation of p16 CpG Islands Associated with Malignant Transformation of Gastric Dysplasia in a Population-Based Study. Clin Cancer Res. 2004 ;10(15):5087-93.

15. Luying Liu #, Yu Sun* #, Zhongwu Li, Guoshuang Feng, Weicheng You, Jiyou Li. Existence and Significance of Pericryptal Fibroblast Sheath in Intestinal Metaplasia, Dysplasia and Carcinoma of the Stomach A Prospective Study on Biomarkers predicting the progression of Gastric Intestinal Metaplasia. Chin J Cancer Res. 2009;21(4):290-294

16. Sun Y, Shi YF, Zhou LX, Chen KN, Li XH. Synchronous pulmonary squamous cell carcinoma and mantle cell lymphoma of the lymph node. Case Rep Genet. 2011;2011:945181. doi: 10.1155/2011/945181. Epub 2011 Jul 2.

17. 王鑫宇，胡雅潔，董坤，趙晨，黃小征，廉沈沂，孫宇. 高度微衛(wèi)星不穩(wěn)定胃癌中PDL1的表達(dá)水平及其預(yù)后價(jià)值 中華病理學(xué)雜志 2020, 49 (11):1114-1119 (通訊作者)

18. 賴玉梅，馮勤，孫宇，王萍，時(shí)云飛，趙敏，吳琪，李向紅. 表皮生長(zhǎng)因子受體基因突變性抗體在肺腺癌中的表達(dá) 中華病理學(xué)雜志,2016,45(9):606-611(通訊作者)

19. 王晰程，孫宇，高靜，鄭建萍，沈琳. 人表皮生長(zhǎng)因子受體2在直腸癌手術(shù)切除標(biāo)本與活檢標(biāo)本表達(dá)的一致性研究 中華胃腸外科雜志 2015;18(6):597-601(通訊作者)

20. 張和平，孫宇，黃小征，賈玲，白艷花，曹登峰. 腹膜黏液性腫瘤臨床病理特征分析及其起源探討 中華病理學(xué)雜志 2014;43(3):163-168(通訊作者)

21. 周冬梅，孫宇，李向紅. 微管相關(guān)蛋白-2在240例活檢肺小細(xì)胞癌中的診斷價(jià)值，中華病理學(xué)雜志 2013;42(5)：321-324(通訊作者)

22. 孫宇，周立新，趙敏，李向紅. 肺硬化性血管瘤組織起源的探討, 中華病理學(xué)雜志 2012;41(4)：239-242

23. 孫宇，李吉友. 食管胃結(jié)合部腺癌臨床病理特點(diǎn). 中國(guó)實(shí)用外科雜志 2012;32(4)：270-272

24. 張曉玲，孫宇，汪寧，李向紅. 肝穿刺標(biāo)本診斷轉(zhuǎn)移性實(shí)性假乳頭狀腫瘤1例報(bào)道及文獻(xiàn)復(fù)習(xí). 診斷病理學(xué)雜志 2010;17(4)：278-283(通訊作者)

25. 孫宇，劉毅強(qiáng)，馮國(guó)雙，李吉友. 轉(zhuǎn)化生長(zhǎng)因子β1在萎縮性胃炎發(fā)生中的作用. 北京大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)2009;41(6)：635-639

26. 孫宇 ，金曉明，劉彥鋮，張朋旗，畢彥忠，鐘志玖. 胃黏膜腸上皮化生類型與胃癌發(fā)生的關(guān)系. 哈爾濱醫(yī)科大學(xué)學(xué)報(bào) 2000;34(3):160-162