高翔宇，青年北京學者、研究員、副主任醫(yī)師、副教授、博士生導師。北京大學腫瘤醫(yī)院暨北京市腫瘤防治研究所胃腸腫瘤中心、消化系腫瘤整合防治全國重點實驗室、癌癥整合組學前沿科學中心、惡性腫瘤轉(zhuǎn)化研究北京市重點實驗室、北京大學臨床醫(yī)學高等研究院。北京大學、Cardiff University雙博士學位（M.D., Ph.D.）。主要臨床方向：基于外科的胃癌及腸癌圍術期個體化診療。研究方向：圍術期綜合治療前后免疫微環(huán)境的時空演進機制及重塑規(guī)律。近五年以通訊/第一作者在Nature Medicine（2024、2025）, Lancet Oncology, Science Advances, Cancer Research, Nature Review Clinical Oncology等雜志發(fā)表SCI論文，主持國家自然科學基金面上項目、國家自然科學基金重大研究計劃集成項目等10項省部級課題，已授權國家發(fā)明專利3項，參與編撰專著1部。國際胃癌學會成員（IGCA）、中國抗癌協(xié)會青年理事會理事、中國抗癌協(xié)會胃癌整合防篩專委會常務委員、北京整合醫(yī)學學會胃腸外科分會常委、MedComm編委，F(xiàn)undamental Research青年編委，Chinese Journal of Cancer Research青年編委，中華胃腸外科雜志青年審稿專家，獲得中華醫(yī)學科技獎一等獎（5/15）。入選青年北京學者、北京市醫(yī)管局“青苗”、北京大學首屆臨床科學家、北京大學騰云青年科學家等人才計劃，2024第四屆“人民好醫(yī)生·金山茶花計劃”金獎，研究論文獲評“2023-2024年度中國消化道腫瘤領域十佳臨床研究”。

發(fā)表論文

1.Lin Shen#, Yanqiao Zhang#, Ziyu Li# Xiaotian Zhang#, Xiangyu Gao#, Bo Liu, Yusheng Wang, Yi Ba, Ning Li, Ruixing Zhang, Jingdong Zhang, Ye Chen, Jian Chen, Mingzhu Huang, Yang Fu, Mulin Liu, Zheng Liu , Jun Zhao, Wei Li, Jia Wei, Changzheng Li, Nong Xu, Zengqing Guo, Bangwei Cao, Lian Liu, Peng Nie, Lixin Wan, Lili Sheng, Zhenyang Liu, Yifu He, Kangsheng Gu, Guowu Wu, Weibo Wang, Futong Zhang, Wensheng Qiu, Jun Guo, Jieer Ying, Hongming Pan, Huiting Xu, Yuan Yuan, Yuansong Bai, Zhenghua Wang, Jiye Xu, Xuehong Zhao, Hao Liu, Xizhi Zhang, Wenxiang Dai, Hongyan Xu, Ming Liu, Lin Xie, Yong Tang, Jianying Jin, Xiujuan Qu, Xuefeng Fang, Mingwei Huang, Hao Chen, Zhendong Zheng, Ying Wang, Daqing Wang, Xiaoqin Li, Guohua Yu, Haiyan Liu, Yongjian Zhou, Diansheng Zhong, Shan Zeng, Mafei Kang, Meiqing Wang, Yong Gao, Wenxin Li, Zejun Wang, Minghui Zhang, Jinghua Zhang, Qingshan Li, Shujuan Sun, Aimin Zang, Lizhu Lin, Ming Xie, Zhixiang Zhuang, Tao Zhang, Zhifang Yao, Dongmei Lu, Wei Liu, Mingxiu Hu, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Jiajia Zhang, Xiangji Ying, Drew M Pardoll, Jiafu Ji*. First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial. Nature Medicine. 2025 Jan 22.

2.Xiaoyong Guo#, Shuangling Luo#, Xiaofeng Wang#, Yingying Cui#, Miaomiao Li#, Zeyu Zhang, Lidan Fu, Caiguang Cao, Xiaojing Shi, Haifeng Liu, Yawei Qu, XiangyuGao*, Huzhen Hua*, Jie Tain*. CD24-Targeted NIR-II Fluorescence Imaging Enables Early Detection of Colorectal Neoplasia. Cancer Research. 2024 Sep 17. 

3.Xiangyu Gao#, Ke Ji#, Yongning Jia#, Fei Shan#, Ye Chen#, Nong Xu#,  Ziyu Jia#, Tianshu Liu, Nong Yang, Haijun Zhong, Changzheng Li, Zengqing Guo, Qingxia Fan, Xiaoyan Lin, Yan Zhang, Hui Ren, Hongxia Yang, Zhifang Yao, Wei Liu, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Lin Shen*, Ziyu Li*, Jiafu Ji* .Cadonilimab with chemotherapy in unresectable HER2-negative gastric or gastroesophageal junction adenocarcinoma (COMPASSION-04): a phase 1b/2 trial. Nature Medicine. 2024 Jul; 30(7): 1943-1951. 

4.Xiangyu Gao#, Nong Xu#, Ziyu Li#, Lin Shen#, Ke Ji#, Zhong Zheng#, Dan Liu, Hanmei Lou, Li Bai, Tianshu Liu, Yunxia Li, Yuzhi Li, Qingxia Fan, Mei Feng, Haijun Zhong, Yi Huang, Ge Lou, Jing Wang, Xiaoyan Lin, Ye Chen, Ruifang An, Changzheng Li, Qi Zhou, Xin Huang, Zengqing Guo, Shubin Wang, Guiling Li, Junwei Fei, Lijing Zhu, Hong Zhu, Xiumin Li, Fenghu Li, Sihai Liao, Qinghua Min, Lei Tang, Fei Shan, Jifang Gong, Yunong Gao, Jun Zhou, Zhihao Lu, Xiaofan Li, Jianjie Li, Hui Ren, Xiaohong Liu, Hongxia Yang, Wenting Li, Weifeng Song, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Xiaohua Wu*, Jiafu Ji*. Safety and antitumour activity of Cadonilimab, an anti-PD-1/CTLA-4 bispecific antibody, for patients with advanced solid tumours (AK104-201): a multicentre, open-label, phase 1b/2 trial. Lancet Oncology. 2023 Oct; 24(10):1134-1146. 

5.Ziyu Li#, Xiangyu Gao#, Xinxin Peng#, Mei-Ju May Chen#, Zhe Li#, Bin Wei, Xianzi Wen, Baoye Wei, Yu Dong, Zhaode Bu, Aiwen Wu, Qi Wu, Lei Tang, Zhongwu Li, Yiqiang Liu, Li Zhang , Shuqin Jia , Lianhai Zhang, Fei Shan, Ji Zhang, Xiaojiang Wu, Xin Ji , Ke Ji, Xiaolong Wu, Jinyao Shi, Xiaofang Xing, Jianmin Wu, Guoqing Lv, Lin Shen, Xuwo Ji, Han Liang*, Jiafu Ji*; Multi-omics Characterization of Molecular Features of Gastric Cancer Correlated with Response to Neoadjuvant Chemotherapy. Science Advances. 2020 Feb 26;6(9):eaay4211.