詹啟敏，中國工程院院士、北京大學(xué)博雅講席教授，北京大學(xué)校務(wù)委員會(huì)副主任。擔(dān)任北京大學(xué)國際癌癥研究院院長，北京大學(xué)健康醫(yī)療大數(shù)據(jù)國家研究院院長、北京大學(xué)腫瘤醫(yī)院分子腫瘤學(xué)實(shí)驗(yàn)室主任。擔(dān)任蘇州大學(xué)蘇州醫(yī)學(xué)院院長。北京大學(xué)原常務(wù)副校長，北京大學(xué)原醫(yī)學(xué)部主任。

教育部長江學(xué)者，國家杰出青年基金獲得者，國家自然科學(xué)基金委創(chuàng)新群體首席專家，國家973重大基礎(chǔ)研究項(xiàng)目首席科學(xué)家。英國國王大學(xué)(Kings College)榮譽(yù)教授，英國曼切斯特大學(xué)(University of Manchester)榮譽(yù)教授，日本順天堂大學(xué)客座教授，日本慶應(yīng)義塾大學(xué)客座教授。

現(xiàn)任中國醫(yī)師協(xié)會(huì)副會(huì)長、中國抗癌協(xié)會(huì)副理事長、中國醫(yī)療保健國際交流促進(jìn)會(huì)副會(huì)長、中國微循環(huán)學(xué)會(huì)副理事長、歐美同學(xué)會(huì)海外醫(yī)師協(xié)會(huì)會(huì)長。國家科技部生物技術(shù)發(fā)展戰(zhàn)略咨詢專家委員會(huì)主任，國家衛(wèi)健委科技創(chuàng)新專家委員會(huì)副主任，國務(wù)院學(xué)位委員會(huì)第八屆學(xué)科評(píng)議組(臨床醫(yī)學(xué)和醫(yī)學(xué)技術(shù)組)召集人”，第五屆國家科學(xué)技術(shù)獎(jiǎng)勵(lì)委員會(huì)委員。

主要致力于腫瘤分子生物學(xué)和轉(zhuǎn)化醫(yī)學(xué)研究，在細(xì)胞周期調(diào)控、基因組穩(wěn)定性和細(xì)胞癌變機(jī)制研究中取得原創(chuàng)性和系統(tǒng)性成果，從較深的層面揭示了抑癌基因在調(diào)控細(xì)胞周期和維持基因組穩(wěn)定性中的功能，豐富了人們對(duì)抑癌基因在細(xì)胞周期檢測點(diǎn)、基因組穩(wěn)定性和基因調(diào)控中生物學(xué)作用的認(rèn)識(shí)。在基因組水平全面系統(tǒng)的揭示了食管鱗癌的遺傳突變背景，為了解食管鱗癌的發(fā)病機(jī)理、尋找食管鱗癌診斷的分子標(biāo)志物、確定研發(fā)臨床治療的藥物靶點(diǎn)以及制定有效治療方案提供了理論和實(shí)驗(yàn)依據(jù)。在國際醫(yī)學(xué)生物學(xué)雜志上發(fā)表學(xué)術(shù)論文270余篇，包括Nature、Cell、Science、Cell Research、STTT、JCI、PNAS、EMBO、Molecular Cancer、JEV、Cancer Research、Oncogene等。出版學(xué)術(shù)著作7部，獲得授權(quán)專利15項(xiàng)。應(yīng)邀在國內(nèi)外學(xué)術(shù)會(huì)議上作大會(huì)報(bào)告120余次，15次擔(dān)任國際學(xué)術(shù)會(huì)議主席。

榮獲教育部自然科學(xué)一等獎(jiǎng)，華夏醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng)，中國抗癌協(xié)會(huì)科技一等獎(jiǎng)，獲國家科技部“十一五”國家科技計(jì)劃執(zhí)行突出貢獻(xiàn)獎(jiǎng)，中國研究型醫(yī)院協(xié)會(huì)中國醫(yī)學(xué)科學(xué)家獎(jiǎng)，中國微循環(huán)學(xué)會(huì)終身成就獎(jiǎng)。被鳳凰網(wǎng)評(píng)為改革開放《致敬四十年盛典“時(shí)代人物”》(2018)，“健康中國(2019)? 十大年度人物”，“樹蘭醫(yī)學(xué)獎(jiǎng)(2021)”，“十大醫(yī)學(xué)杰出貢獻(xiàn)專家(2022)”。

代表性論文

1. Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014, 509(7498):91-95. IF=49.962.

2. Dongdong Zhang, Weimin Zhang, Dan Li, Ming Fu, Runsheng Chen, Qimin Zhan. GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3. Autophagy. 2015, 11(12): 2247-2258. IF=16.016.

3. Dan Li, Xuefeng Liu, Jian Zhou, Jie Hu, Dongdong Zhang, Jing Liu, Yanyan Qiao, Qimin Zhan. Long noncoding RNA HULC modulates the phosphorylation of YB-1 through serving as a scaffold of extracellular signal-regulated kinase and YB-1 to enhance hepatocarcinogenesis. Hepatology. 2017, 65(5):1612-1627. IF=17.425.

4. Zhang, W., R. Hong, L. Li, Y. Wang, P. Du, Y. Ou, Z. Zhao, X. Liu, W. Xiao, D. Dong, Q. Wu, J. Chen, Y. Song and Q. Zhan. The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment. Molecular Cancer. 2018;17:125. IF=27.401.

5. Wu, Q., W. Zhang, L. Xue, Y. Wang, M. Fu, L. Ma, Y. Song and Q. Zhan. APC/C-CDH1-Regulated IDH3beta Coordinates with the Cell Cycle to Promote Cell Proliferation. Cancer Research. 2019;79:3281-93. IF=12.701.

6. Li, X., L. Shi, Y. Wang, J. Zhong, X. Zhao, H. Teng, X. Shi, H. Yang, S. Ruan, M. Li, Z. S. Sun*, Q. Zhan* and F. Mao*. OncoBase: a platform for decoding regulatory somatic mutations in human cancers, 2019. Nucleic Acids Research. 2019, 47(D 1): D1044-D1055. IF=16.971.

7. Yan T, Cui H, Zhou Y, Yang B, Kong P, Zhang Y, Liu Y, Wang B, Cheng Y, Li J, Guo S, Xu E, Liu H, Cheng C, Zhang L, Chen L, Zhuang X, Qian Y, Yang J, Ma Y, Li H, Wang F, Liu J, Liu X, Su D, Wang Y, Sun R, Guo S, Li Y, Cheng X, Liu Z, Zhan Q*, Cui Y*. Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nature Communications. 2019, 10(1): 1670. IF=14.919.

8. Cui Y, Chen H, Xi R, Cui H, Zhao Y, Xu E, Yan T, Lu X, Huang F, Kong P, Li Y, Zhu X, Wang J, Zhu W, Wang J, Ma Y, Zhou Y, Guo S, Zhang L, Liu Y, Wang B, Xi Y, Sun R, Yu X, Zhai Y, Wang F, Yang J, Yang B, Cheng C, Liu J, Song B, Li H, Wang Y, Zhang Y, Cheng X, Zhan Q*, Li Y*, Liu Z*. Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma. Cell Research. 2020, 30(10): 902-913. IF=12.701.

9. Liu, J., C. Li, J. Wang, D. Xu, H. Wang, T. Wang, L. Li, H. Li, P. Nan, J. Zhang, Y. Wang, C. Huang, D. Chen, Y. Zhang, T. Wen*, Q. Zhan*, F. Ma* and H. Qian*. Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing. Nature Communications. 2020;11:4455. IF=14.919.

10. Jie Chen, Yan Wang, Weimin Zhang, Di Zhao, Lingyuan Zhang, Jiawen Fan, Jinting Li, Qimin Zhan. Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells. Signal Transduction and Targeted Therapy. 2020, 5(139): 1-12. IF=18.187.

11. Xiao W, Yeerken D, Li J, Li Z, Jiang L, Li D, Fu M, Ma L, Song Y, Zhang W, Zhan Q. Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. Signal Transduction and Targeted Therapy. 2021 04 16;6(1). IF=18.1873.

12. Dong, D., W. Zhang, W. Xiao, Q. Wu, Y. Cao, X. Gao, L. Huang, Y. Wang, J. Chen, W. Wang and Q. Zhan. A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward Loop Promotes Esophageal Squamous Cell Carcinoma Progression. Cancer Research. 2021;81:910-22. IF=12.701.

13. Wang Y, Zhang W, Liu W, Huang L, Wang Y, Li D, Wang G, Zhao Z, Chi X, Xue Y, Song Y, Liu X, Zhan Q. Long noncoding RNA VESTAR regulates lymphangiogenesis and lymph node metastasis of esophageal squamous cell carcinoma by enhancing VEGF-C mRNA stability. Cancer Research. 2021 06 15;81(12). IF=12.701.

14. Gao, X., Y. Wang, F. Lu, X. Chen, D. Yang, Y. Cao, W. Zhang, J. Chen, L. Zheng, G. Wang, M. Fu, L. Ma, Y. Song and Q. Zhan. Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway. Journal of Extracellular Vesicles. 2021, 10(5): e12060. IF=25.841.

15. Gong W, Xu J, Wang Y, Min Q, Chen X, Zhang W, Chen J, Zhan Q. Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma. Signal Transduction and Targeted Therapy. 2022 02 14;7(1). IF=18.187.