教授、博士生導(dǎo)師、北京大學(xué)腫瘤研究中心副主任

美國University of Texas MD Anderson Cancer Center和美國 University of Virginia Cancer Center博士后(1994-1998)，瑞典Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology助理教授、副教授(1998-2008)，北京大學(xué)教授(2008-)?，F(xiàn)任北京大學(xué)人體解剖與組織胚胎學(xué)系主任、腫瘤研究中心副主任、基礎(chǔ)醫(yī)學(xué)院分子細(xì)胞生物學(xué)與腫瘤生物學(xué)實(shí)驗(yàn)室主任。作為課題組長，獲瑞典卡羅琳斯卡醫(yī)科大學(xué)、瑞典醫(yī)學(xué)會(huì)、瑞典癌癥研究基金會(huì)和瑞典研究委員會(huì)和北京大學(xué)985 II期工程等的多項(xiàng)科學(xué)基金資助。目前擔(dān)任國家科技部973課題負(fù)責(zé)人、國家自然科學(xué)基金面上及重點(diǎn)項(xiàng)目的負(fù)責(zé)人、教育部博士點(diǎn)基金和北京市自然科學(xué)基金重大項(xiàng)目負(fù)責(zé)人。1992年獲軍隊(duì)科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)。1993年獲軍事醫(yī)學(xué)科學(xué)院優(yōu)秀青年科技工作者稱號(hào)。2006年獲瑞典卡羅琳斯卡醫(yī)科大學(xué)癌癥研究年度一等獎(jiǎng)。

電話：82802424

郵箱：Hongquan.zhang@bjmu.edu.cn

主要研究領(lǐng)域

腫瘤侵襲轉(zhuǎn)移的分子細(xì)胞生物學(xué)機(jī)制。主要研究興趣在跨膜受體整合素胞內(nèi)結(jié)構(gòu)域相互作用蛋白所介導(dǎo)的腫瘤增殖、侵襲、轉(zhuǎn)移和網(wǎng)絡(luò)調(diào)控的分子細(xì)胞生物學(xué)機(jī)制，腫瘤細(xì)胞重編程產(chǎn)生腫瘤干細(xì)胞及其在腫瘤復(fù)發(fā)和轉(zhuǎn)移中的作用機(jī)制。

代表性研究成果

1. 發(fā)現(xiàn)整合素相關(guān)蛋白Kindlin-2在前列腺癌細(xì)胞中調(diào)控一線抗前列腺癌藥物順鉑的敏感性。首先揭示敲低整合素相關(guān)蛋白Kindlin-2會(huì)提高順鉑對前列腺癌細(xì)胞的殺傷能力。該研究結(jié)果2010年發(fā)表在《Cancer Lett》上，并被推薦為藥物領(lǐng)域Faculty 1000必讀論文。

2. 發(fā)現(xiàn)整合素相關(guān)蛋白Kindlin-2可以在細(xì)胞核內(nèi)與Wnt信號(hào)通路的重要調(diào)控分子β-catenin及Wnt信號(hào)的重要靶基因TCF4形成三分子復(fù)合物，增強(qiáng)Wnt信號(hào)通路的激活。首先揭示出Kindlin-2在細(xì)胞核內(nèi)的生物學(xué)功能及調(diào)控EMT的復(fù)雜機(jī)制。該研究結(jié)果2012年發(fā)表在《EMBO Rep》上，并被推薦為細(xì)胞生物學(xué)領(lǐng)域Faculty 1000必讀論文。

3. 發(fā)現(xiàn)整合素相關(guān)蛋白Kindlin-2在腎上皮細(xì)胞中與TGF-β I型受體及Smad3相互作用，調(diào)控EMT及腎臟的纖維化。該研究結(jié)果2013年發(fā)表在《J Am Soc Nephrol》上，雜志還撰寫了專題評述。

4. 發(fā)現(xiàn)組蛋白甲基轉(zhuǎn)移酶EZH2可以被乙酰轉(zhuǎn)移酶PCAF乙酰化;EZH2還可以被去乙?；窼IRT1去乙?；?乙酰化的EZH2可以增加自身的穩(wěn)定性，并在肺腺癌的預(yù)后中起作用。該研究結(jié)果2015年發(fā)表在《Nucleic Acids Research》上。

近五年代表性論文

1. Junhu Wan, Jun Zhan, Shuai Li, Ji Ma, Weizhi Xu, Chang Liu, Xiaowei Xue, Yuping Xie, Weigang Fang, Y. Eugene Chin and Hongquan Zhang* (2015) PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression. Nucleic Acids Research doi: 10.1093/nar/gkv238.

2. Baohui Guo, Jianchao Gao, Jun Zhan, Hongquan Zhang* (2015) Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced breast cancer cell migration. Cancer Lett 361:271-81

3. Zhan J, Song J, Wang P, Chi X, Wang Y, Guo Y, Fang W*, Zhang H* (2015) Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9. Cancer Lett 361:75-85

4. Zhan J, Niu M, Wang P, Zhu X, Li S, Song J, He H, Wang Y, Xue L, Fang W, Zhang H* (2014) Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients. Br J Cancer. 111:883-93

5. Liu Y, Guan L, Zhan J, Lu D, Wan J, Zhang H* (2014) FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration. FEBS Lett 588:2859-66

6. Wei X, Wang X, Xia Y, Tang Y, Li F, Fang W, Zhang H* (2014) Kindlin-2 regulates renal tubular cell plasticity by activation of Ras and its downstream signaling. Am J Physiol Renal Physiol 306:F271-8

7. Wei X, Xia Y, Li F, Tang Y, Nie J, Liu Y, Zhou Z, Zhang H*, Hou FF* (2013) Kindlin-2 Mediates Activation of TGF-β/Smad Signaling and Renal Fibrosis. J Am Soc Nephrol 9:1387-98

8. Ting Zhao, Lizhao Guan, Yu Yu, Xuelian Pe, Jun Zhan, Ling Han, Yan Tang, Feng Li, Weigang Fang*, Hongquan Zhang* (2013) Kindlin-2 promotes genome instability in breast cancer cells. Cancer Lett 330:208-16

9. Yu Yu, Junzhou Wu, Lizhao Guan, Lihua Qi, Yan Tang, Bo Ma, Jun Zhan, Yunling Wang, Weigang Fang and Hongquan Zhang* (2013) Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family. Int J Cancer 133: 1368-79

10. Yu Yu, Junzhou Wu, Yunling Wang, Ting Zhao, Bo Ma, Yuqing Liu, Weigang Fang, Wei-Guo Zhu and Hongquan Zhang* (2012) Kindlin-2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signaling. EMBO Rep 8:750-8

11. Chang Liu, Shuai Li, Xiaoyan Dai, Ji Ma, Junhu Wan, Hao Jiang, Peng Wang, Zhaoli Liu and Hongquan Zhang* (2015) PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex. Nucleic Acids Research, doi: 10.1093/nar/gkv574

12. Junhu Wan, Jun Zhan, Shuai Li, Ji Ma, Weizhi Xu, Chang Liu, Xiaowei Xue, Yuping Xie, Weigang Fang, Y. Eugene Chin and Hongquan Zhang* (2015) PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression. Nucleic Acids Research 43: 3591–3604.

實(shí)驗(yàn)室成員

研究人員：于宇、戰(zhàn)軍、遲曉春、梅芳、祁麗花、魏瀟凡、杜鵑

技術(shù)人員：唐巖、李峰、呂丹瑜、張京、畢振武